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Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers
Author(s) -
HäyrinenImmonen Ritva,
Sorsa Timo,
Pettilä Juha,
Konttinen Yrjö T.,
Teronen Olli,
Malmstrom Maria
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb00057.x
Subject(s) - collagenase , saliva , doxycycline , chlortetracycline , fibroblast , recurrent aphthous stomatitis , medicine , in vitro , antibiotics , gastroenterology , immunology , chemistry , stomatitis , enzyme , biochemistry
Human neutrophil‐type (MMP‐8) and fibroblast‐type (MMP‐1) interstitial collagenase, and their inhibition by tetracyclines in saliva from patients with recurrent aphthous ulcers (RAU) or aphthae, were studied by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) and enzymological analyses. In the salivary specimens obtained from patients with aphthae, collagenase was found in endogenously active form and was predominantly of MMP‐8 type. Topical rinsing treatment with chlortetracycline (Aureomycin®) alleviated the discomfort caused by the lesions but did not reduce salivary collagenase amounts; however in vitro , doxycycline inhibited salivary collagenase totally.