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VCAM‐1 and ICAM‐1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus
Author(s) -
Walton L J.,
Thornhill M. H.,
Farthing P. M.
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb00056.x
Subject(s) - vcam 1 , lamina propria , pathology , oral lichen planus , staining , icam 1 , biology , cell adhesion molecule , endothelium , antigen , microbiology and biotechnology , epithelium , immunology , medicine , endocrinology
Expression of intercellular adhesion molecule‐1 (ICAAM‐1, CD54) and vascular cell adhesion molecule‐1 (VCAM‐l, CD106) was examined in oral lichen planus (OLP) and normal oral mucosa (NOM). Immunoperoxidase staining showed ICAM‐1 expression by vascular endothelium in all biopsies of OLP and NOM whereas endothelial VCAM‐l staining was found in 2/7 NOM and 8/9 OLP. In the lamina propria of NOM occasional cells were ICAM‐1 or VCAM‐l positive, and virtually no staining of intraepilhelial dendritic cells was seen for either marker. Intraepithelial dendritic cells stained for ICAM‐1 in 7/9 and VCAM‐1 in 4/9 OLP biopsies. Double immunofluorescence showed dual labelling of Langerhans cells (LC) with CD1a and VCAM‐l in a further 5/12 cases of OLP, but there was no such staining in four NOM. This is the first report of LC staining with VCAAM‐l. Induction of ICAM‐1 and VCAM‐l on LC and macrophages in OLP suggests these cells are activated and may contribute to the pathogenesis of OLP by presenting antigen to infiltrating lymphocytes.