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Discrimination of parakeratinised odontogenic keratocysts from other odontogenic and non‐odontogenic cyst types by expression of a 38kd cell‐surface glycoprotein
Author(s) -
High A. S.,
Robinson P. A.,
Klein C. E.
Publication year - 1993
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1993.tb01090.x
Subject(s) - odontogenic , odontogenic cyst , pathology , glycoprotein , biology , medicine , microbiology and biotechnology
We have identified strong expression of a 38‐kD cell surface glycoprotein (gp38), a marker of basal cell carcinomas (BCCs), in basal and suprabasal epithelial cell membranes of parakeratinised odontogenic keratocysts. In contrast, orthokeratinised cysts and most other odontogenic cyst types, ameloblastomas, normal stratified oral epithelium, cell rests of Malassez and glands of Serres, all proved negative. To our knowledge this is the first histochemical marker to distinguish between these major cyst types. It has obvious uses in the diagnosis of inflamed keratocysts and the separation of ameloblastomas from BCCs and may find a role in studies of the developmental biology of other odontogenic structures.