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Antibodies to mycobacterial stress protein in patients with orofacial granulomatosis
Author(s) -
Ivanyi L.,
Kirby A.,
Zakrzewska J. M.
Publication year - 1993
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1993.tb01081.x
Subject(s) - antibody , medicine , titer , antibody titer , immunology , antigen , crohn's disease , pathology , disease
Immunoglobulin G antibody liters to the mycobacterial stress protein with molecular weight of 65 kDa (mSP65) were determined by ELISA in sera from 10 patients with orofacial granulomatosis (OFG). Four patients with confirmed Crohn's disease had serum antibodies to mSP65 with liters ranging from 400–950. Of six remaining patients, three patients had serum antibodies to mSP65 with titers ranging from 180–850. whilst no serum antibody to this antigen could be detected in 3 patients. However, other laboratory investigations failed to show any consistent pattern of disturbance in the 10 tested. Thus, the presence of serum antibody to mycobacterial 65 kDa stress protein might prove lo be of a diagnostic value for Crohn's disease.