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Immunohistochemical localization of bone morphogenetic protein (BMP) in calcifying fibrous epulis
Author(s) -
Lianjia Yang,
Yan Jin,
Doi Tatsuko,
Sekine Ichiro,
Ogawa Kazuhiro,
Moril Masahiko
Publication year - 1993
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1993.tb00131.x
Subject(s) - epulis , immunohistochemistry , bone morphogenetic protein , bone morphogenetic protein 2 , pathology , medicine , anatomy , biology , biochemistry , in vitro , gene
Immunohistochemical detection of bone morphogenetic protein (BMP) in calcifying fibrous epulis was performed to elucidate the biological process of ossification and cemento‐ossification. In a total 25 cases, 15 (60%) showed positive BMP staining in bone forming areas. Histopathological features of developing hard tissues were varied, consisting of structures such as woven bone and cemento‐osseous formations. BMP immunostaining was limited to osteoblasts and fibrous connective tissue surrounding the bone matrix. BMP was concentrated in the periodontal fibres and in dense fibrous structures in the cemento‐osseous masses. On the basis of histopathological and immunohistochemical features, the histogenesis of ossifying and cemento‐ossifying processes appear to be of two possible origins; the excessive proliferation of periodontal ligament and a meta‐plastic process occurring in the connective tissue fibres (non‐periodontal in origin), with the former being more common.