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Immunohistochemical study of lymphoid tissue in human fetal salivary gland
Author(s) -
Lee S. K.,
Lim C. Y.,
Chi J. G.,
Hashimura K.,
Yamada K.,
Kunikata M.,
Mori M.
Publication year - 1993
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1993.tb00115.x
Subject(s) - lymphatic system , salivary gland , pathology , biology , immunohistochemistry , sublingual gland , submandibular gland , keratin , parotid gland , lymph , lactoferrin , fetus , immunology , endocrinology , medicine , pregnancy , genetics
Immunoreactivity of lysozyme (LY), lactoferrin (LF), α 1 antichymotrypsin (α 1 ‐ACT), α‐antitrypsin (α 1 ‐AT), keratin proteins KL1, PKK1, K8.12, S‐100 protein, MAM‐3, MAM‐6, and epithelial membrane antigen (EMA) were evaluated in lymphoid and glandular tissues of developing salivary gland of human fetus (gestational age ranging from 17 to 40 wk to investigate the role of lymphoid tissue in developing salivary glands. In a total of 79 cases, lymphoid cell aggregations were noted in parotid (57 cases), submandibular (21 cases) and sublingual (5 cases) glands. Mononuclcar cells showing intense activity of LY, α 1 ‐ACT and α 1 ‐AT were present in the lymphoid aggregation. The glandular ducts embedded in lymphoid tissue were negative to MAM‐3, MAM‐6, EMA and S‐100 protein, but showed positive PKK1 and KL1 reaction during early stages of development, and showed degeneration and effacement upon increase in number and LY activity of the mononuclear cells. The lymphoid aggregations progressively emerged as lymph nodes.