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Experimentally induced ameloblastomas: a critical review
Author(s) -
Gardner D. G.
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb01360.x
Subject(s) - ameloblastoma , medicine , dentistry , maxilla
This article reviews the experimental induction of ameloblastomas with emphasis on the acceptability of the induced tumors as being truly equivalent to amelobastomas in humans. Attempts to induce odontogenic tumors in experimental animals have been made sporadically since the early 1960's but the yield of ameloblastomas has been low. Tumors resembling ameloblastomas. but not completely typical histologically and apparently lacking the invasive qualities of ameloblastoma, have been produced in mice using polyoma virus. However, the most typical ameloblastomas have been those induced in opossums, using ethylnitrosourea. Consequently, it is recommended that this model be used in any further attempts to produce ameloblastomas experimentally.