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Effect of benzoyl peroxide on two‐stage oral carcinogenesis and gamma‐glutamyl transpeptidase in hamsters
Author(s) -
Zhang L.,
Mock D.
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb01009.x
Subject(s) - dmba , carcinogen , benzoyl peroxide , hamster , carcinogenesis , glutathione , medicine , endocrinology , chemistry , gamma glutamyltransferase , 7,12 dimethylbenz[a]anthracene , biochemistry , enzyme , biology , cancer , organic chemistry , polymerization , polymer
Hamster buccal pouches were treated with 7,l2‐dimethylbenz(a)anthracene (DMBA) triweekly for 3 wk and subsequently with 40% benzoyl peroxide (BP) in actone for up to 27 wk. BP treatment resulted in a marked hyperplasiogenic effect and a weak tumor promoting effect. Whereas most carcinogens and tumor promoters induce gamma‐glutamyl transpeptidase (GGT) activity, BP diminished its activity as compared to controls. Comparable results have also been noted in the liver, where a group of newly isolated hepatocareinogens, peroxisome proliferators (PP), also characteristically deplete the GGT activity and placental glutathione S‐transferase (GST‐P), another tumor marker.