Effect of ionizing radiation on sympathetic nerve function in rat parotid glands | Zendy

Kohn W. G. | Zendy; Grossman E. | Zendy; Fox P. C. | Zendy; Armando I. | Zendy; Goldstein D. S. | Zendy; Baum B. J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Effect of ionizing radiation on sympathetic nerve function in rat parotid glands

Author(s) -

Kohn W. G.,

Grossman E.,

Fox P. C.,

Armando I.,

Goldstein D. S.,

Baum B. J.

Publication year - 1992

Publication title -

journal of oral pathology and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.887

H-Index - 83

eISSN - 1600-0714

pISSN - 0904-2512

DOI - 10.1111/j.1600-0714.1992.tb00997.x

Subject(s) - parotid gland , endocrinology , medicine , catecholamine , ionizing radiation , ventricle , saliva , salivary gland , dopamine , serous fluid , chemistry , pathology , irradiation , physics , nuclear physics

Ionizing radiation (IR) irreversibly damages salivary glands. The pathologic mechanism is unknown. Previously we reported that parotid serous acinar cells may not be the primary site of damage by IR. The purpose of this study was to determine if IR alters sympathetic nerve function in rat parotid glands. Male adult rats received a single dose of radiation (20 Gy) to the head and neck. Three days after IR, parotid saliva secretion induced by norepinephrine (NE) was completely blocked. Catecholamine uptake and metabolism were studied by injecting [ 3 H] dopamine ([ 3 H]DA) into irradiated rats, as a bolus. After 60 min, animals were sacrificed and the parotid gland, submandibular gland, and left ventricle removed. Tissue contents of [ 3 H]DA and [ 3 H]NE, identified by HPLC, were unaffected by IR. The results indicate that IR abolishes acinar responsiveness to NE without affecting parotid sympathetic nerve function.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research