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Immunohistochemical localization of c‐ myc oncogene product in oral papilloma
Author(s) -
Satoh Masanobu,
Sashima Mieko,
Hatakeyama Setsuko,
Yoshimura Noriko,
Otsu Tadashi,
Suzuki Atsumi
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb00989.x
Subject(s) - immunohistochemistry , oncogene , cytoplasm , papilloma , pathology , oral lichen planus , biology , basal (medicine) , cell , cancer research , medicine , microbiology and biotechnology , cell cycle , endocrinology , genetics , insulin
The expression of c‐ myc oncogene products in oral papillomas was studied by using an immunohistochemical method. The oncogene products were detected in 17(70.8%) of the 24 oral papillomas under study. The expression of the products was evaluated, and the histologic localization in proliferating epithelial cells of the oral papillomas was determined. In the basal cell layer, the products were detected in the nuclei of 16 oral papillomas, and in the cytoplasm of 12 oral papillomas. In the nuclei of cells in the spinous cell layer, the products were detected in 4 oral papillomas, and in the cytoplasm of 13 oral papillomas. In the keratinized cells, the products were not detected in the nuclei, but they were identified in the cytoplasm of three oral papillomas. The results suggested that the c‐ myc oncogene product might play an important role for proliferation and differentiation of the oral papilloma.