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Expression of the CD54 (ICAM‐1) and CD11 a (LFA‐1) adhesion molecules in oral mucosal inflammation
Author(s) -
Verdickt Gary M.,
Savage Neil W.,
Dodd Nicole M.,
Walsh Laurence J.
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb00981.x
Subject(s) - intraepithelial lymphocyte , inflammation , cell adhesion molecule , pathology , antigen , immunology , intercellular adhesion molecule , oral lichen planus , intercellular adhesion molecule 1 , immunoperoxidase , biology , epithelium , medicine , cell adhesion , cell , antibody , monoclonal antibody , genetics
Previous studies of chronic dermatoses have suggested that expression of the CD54 cell surface antigen (intercellular adhesion molecule‐1, ICAM‐1) by keratinocytes is a feature of chronic inflammation. However, whether such expression is a prerequisite for intraepithelial migration of lymphocytes is unclear. The present study evaluated the expression of CD54 and its ligand, CD1 la (lymphocyte function‐associated antigen, LFA‐1) in oral lesions of lichen planus, recurrent aphthous stomatitis, secondary Sjögren's syndrome and traumatic ulceration using an immunoperoxidase technique. In 33 of 56 lesions examined, substantial numbers of CD1 la + cells were present within oral mucosal epithelium despite an absence of detectable keratinocyte CD54 antigen expression. Consequently, CD54/CD1 la adhesion interactions may not be critical in the initiation of oral mucosal inflammation.