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Rare expression of the c‐erbB‐2 oncoprotein in salivary gland tumors: an immunohistochemical study
Author(s) -
Shrestha Prashanta,
Huang Jian Wen,
Tsujr Tatsuo,
Shinozaki Fumihiko,
Maeda Kanji,
Sasaki Kohsuke,
Ueno Kousaku,
Yamada Kazuto,
Mori Masahiko
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb00978.x
Subject(s) - mucoepidermoid carcinoma , salivary gland , pathology , immunohistochemistry , pleomorphic adenoma , biology , pleomorphism (cytology) , histopathology , medicine
An immunohistochemical study of c‐erbB‐2 oncoprotein expression was carried out on 201 cases of primary salivary gland tumors, using a polyclonal antibody, raised to the intracytoplasmic domain of the c‐erbB‐2 oncogene product. An intense membrane reactivity was observed in one case of sialocarcinoma transformed from pleomorphic adenoma ( n = 8) and one case of mucoepidermoid carcinoma ( n = 22). A comparative histopathologic evaluation of c‐erbB‐2 positive tumors showed marked variation in cell size, nuclear pleomorphism, multinucleation, a high mitotic rate and increased lymphoid cell infiltration and an aggressive clinical course with poor survival. The results indicate that c‐erbB‐2 oncoprotein is rarely expressed in malignant salivary gland tumors. However, the overexpression appears to have a distinct histopathologic feature, but a larger study incorporating histopathology and clinical data would be necessary to correlate the significance of c‐erbB‐2 oncogene product in salivary malignant tumors.