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Immunoreaction of keratin, actin, S‐100 protein and rat‐EGF in ductligated rat salivary glands
Author(s) -
Hashimoto J.,
Yamada K.,
Ogata K.,
Takai Y.,
Mori M.
Publication year - 1992
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1992.tb00104.x
Subject(s) - myoepithelial cell , salivary gland , sublingual gland , submandibular gland , staining , keratin , pathology , ductal cells , biology , immunohistochemistry , duct (anatomy) , acinus , endocrinology , anatomy , medicine , pancreas
Duct‐ligated submandibular and sublingual glands of rats were evaluated immunohistochemically for changes in keratin (MoAb 1164), actin, S‐100 protein and rat‐EGF (rEGF). Normal salivary glands were reactive for keratin, S‐100 protein and rEGF in the granular convoluted tubule (GCT) and duct cells, and for actin in the myoepithelium. Submandibular glands showed a marked reduction of S‐100 protein and rEGF staining following duct ligation, and no increased staining of proliferating epithelial cells of the late stage in duct ligated glands. Sublingual glands revealed no marked changes for actin staining in myoepithelial cells, irrespective of atrophic changes occurring in acinar and duct cells after duct ligation. Immunohistochemical patterns differed for each type of gland; changes associated with the obstructive lesion were more prominent in the submandibular gland.