Premium
Phenotyping of immunocompetent cells in normal labial and palatal salivary glands and in non‐autoimmune sialadenitis
Author(s) -
Vigneswaran N.,
Peters KP.,
Diepgen T. L.,
Wahlich C.,
Hornstein O. P.,
Haneke E.
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00941.x
Subject(s) - sialadenitis , minor salivary glands , pathology , salivary gland , autoimmune disease , immunology , biology , immune system , antigen , cell type , medicine , antibody , cell , genetics
Different types of inflammatory cells in healthy major and minor salivary glands (SG), including those in labial and palatal non‐autoimmune sialadenitis, were quantified immunohistochemically. Plasma cells, mainly IgA type predominated in all SG types, with the smallest number seen in the palatal glands. The numbers of common leukocyte antigen (CLA) reactive lymphocytes were greater in major SGs than in minor ones and were predominantly UCHLl positive T cell type. Macrophages and neutrophils were absent in palatal glands, rarely present in labial ones and usually present in major SGs. Increases in the number of IgG and IgM plasma cells and lymphocytes (CLA + ) which include both UCHL1 + T and L26 + B cell types, were found in non‐autoimmune labial and palatal sialadenitis. There was no significant correlation between the number of the inflammatory cells and the degree of glandular atrophy in both labial and palatal non‐autoimmune sialadenitis. Increase in their number represents a protective response of these glands in contrast to the inflammatory cells in major autoimmune sialadenitis playing there a pathogenetic role.