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Immunohistochemical investigation in odontogenic myxoma
Author(s) -
Takahashi Hiroshi,
Fujita Shuichi,
Okabe Haruo
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00903.x
Subject(s) - vimentin , odontogenic myxoma , pathology , cytokeratin , s100 protein , biology , desmin , immunohistochemistry , transferrin , hepatic stellate cell , microbiology and biotechnology , medicine , odontogenic , endocrinology
Three odontogenic myxomas are described immunohistochemically by a panel of poly‐ and monoclonal antibodies to characterize this tumor type. Three types of odontogenic myxoma cells were discriminated: spindle cells, stellate cells and hyaline cells. Neoplastic cells of myxomas were positively stained for transferrin, ferritin. alpha‐ 1‐antichymotrypsin (α 1 ‐ACT), alpha‐ 1‐antitrypsin (α 1 ‐AT), S‐100 protein and vimentin; however, neuron specific enolase (NSE), S‐100 α subunit, S‐100 β subunit, Factor VIII‐related antigen (FVIII‐AG) and cytokeratin (CK1) were negative. Spindle cells were positive for transferrin, ferritin, α 1 ‐ACT, α 1 ‐AT, S‐100 protein and vimentin. Stellate cells were strongly positive for transferrin, α 1 ‐AT, S‐100 protein and vimentin. Hyaline cells reacted with α 1 ‐ACT and α 1 ‐AT. Myxomatous matrix showed negative reaction for all the antibodies used. These results have confirmed that odontogenic myxoma is a tumor of a dual fibroblastic‐histiocytic origin.