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Prognostic implication of silver‐binding nucleolar organizer regions (AgNORs) in oral squamous cell carcinoma
Author(s) -
Sano Kazuo,
Takahashi Hiroshi,
Fujita Shuichi,
Inokuchi Tsugio,
Pe Michael B.,
Okabe Haruo,
Tsuda Nobuo
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00889.x
Subject(s) - basal cell , nucleolus organizer region , pathology , medicine , cancer research , oncology , biology , nucleolus , genetics , cytoplasm
Silver‐binding nucleolar organizer regions (AgNORs) were counted in sections from formalin‐fixed, paraffin‐embedded tissue blocks of oral squamous cell carcinoma. Thirty‐nine cases, that comprised poor prognostic group ( n = 19) and good prognostic group ( n = 20), were examined with respect to the relation between AgNOR counts and histologic grading, and correlation between AgNOR counts and prognosis. The pooled mean AgNOR counts were: Grade 1 carcinomas, 6.39 ±1.67 (mean ± SD; n = 35); Grade 2, 9.74 ± 1.72 ( n = 3). Mean AgNOR count of Grade 3 was 6.19 ± 2.37 ( n = 1). The pooled mean AgNOR count in poor prognostic group was higher than that in good prognostic group. Five‐year survival rate of the cases with high AgNOR counts (≥ 6.5) was significantly lower than that with low AgNOR counts (< 6.5). High AgNOR counts are highly suggestive of poor prognosis in oral squamous cell carcinoma.