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Sequence of changes in rat buccal mucosa induced by zinc deficiency
Author(s) -
Hsu Dora,
Meyer Julia,
Gerson Stanley,
Daniel Jon
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00436.x
Subject(s) - lamina propria , parakeratosis , keratin , zinc deficiency (plant disorder) , biology , lesion , weanling , pathology , epithelium , buccal mucosa , anatomy , endocrinology , medicine , dentistry , micronutrient , oral cavity
In weanling rats, after receiving a zinc‐deficient diet (<1 ppm) for 4 wk, the buccal mucosa appears hyperplastic. This study determines changes at earlier stages of the lesion. After 9 days of deficiency, the keratin layer had partially converted to parakeratosis and thickened, and the size of the capillary bed was increased. After 18 days, the keratin layer was fully parakeratotic and thickened further. The cellular layer was thickened. The mitotic rate was doubled and rate ridges were convoluted. After 27 days, the keratin and cellular layers were further thickened, and the mitotic rate remained elevated. The rate ridges were further convoluted. The number of mast cells was doubled and the size of the vascular bed had increased further. These findings suggest early and late interactions between the epithelium and lamina propria. After four days on a control diet following 27 days of zinc deficiency, the mucosa returned normal.