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Demonstration of Epstein‐Barr virus in scrape material of lateral border of tongue in heart transplant patients by negative staining electron microscopy
Author(s) -
SchmidtWesthausen Andrea,
Gelderblom Hans R.,
Hetzer Roland,
Reichart Peter A.
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00421.x
Subject(s) - tongue , negative stain , pathology , staining , virus , electron microscope , immunosuppression , leukoplakia , epstein–barr virus , biology , medicine , virology , immunology , optics , cancer , genetics , physics
Scrape material from the lateral border of the tongue of 50 heart transplant patients and 20 controls was studied for the presence of EBV by negative staining electron microscopy. Mild oral hairy leukoplakia was observed in two cases. Particles of the herpes virus were found in 20% of the specimens. Controls were negative for EBV. The study has shown that EBV may be expressed at the lateral border of the tongue during immunosuppression, occasionally resulting in the clinical appearance of hairy leukoplakia.