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On the mechanism of drug‐induced gingival hyperplasia
Author(s) -
Brown Ronald S.,
Beaver William T.,
Bottomley William K.
Publication year - 1991
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1991.tb00419.x
Subject(s) - mechanism (biology) , medicine , hyperplasia , drug , dentistry , dermatology , pathology , pharmacology , philosophy , epistemology
Proposed mechanisms of the side effect of drug‐induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissue binding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated.