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Oral senile amyloidosis in senescence accelerated mouse (SAM)
Author(s) -
Sashima Mieko,
Satoh Masanobu,
Suzuki Atsumi
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00864.x
Subject(s) - amyloidosis , amyloid (mycology) , pathology , tongue , immunohistochemistry , connective tissue , senescence , epithelium , biology , medicine
Oral senile amyloidosis in senescence accelerated mouse (SAM) was examined for two SAM sublines (P/2/Iw and R/l/Iw) and for various ages by light microscopy, immunohistochemistry, and electron microscopy. The amyloid deposition, identified by green birefrigence following Congo red stain, was observed only in P/2/Iw. In P/2/Iw, no amyloid deposition was found at age 6 months; however, frequency and extent of such deposits increased with advancing age. Distribution of amyloid deposition was as follows: along papillary layers of mucous epithelium in the tongue, the gingiva, the palate, and the buccal mucosa; foci in connective tissues; along vessels, muscles, and minor salivary glands. Immunohistochemically, the amyloid deposition was positive with anti‐AS SAM serum being raised against a unique amyloid protein AS SAM which probably induced “senile systemic amyloidosis”. P/2/Iw is useful as an animal model of oral senile amyloidosis.