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A transforming Kirsten ras oncogene in an oral squamous carcinoma
Author(s) -
Howell R. E.,
Wong F. S. H.,
Fenwick R. G.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00849.x
Subject(s) - oncogene , transfection , cancer research , head and neck , head and neck squamous cell carcinoma , carcinoma , gene , basal cell , dna , squamous carcinoma , biology , head and neck cancer , pathology , cancer , medicine , genetics , cell cycle , surgery
This investigation has employed the NIH 3T3 cell transfection assay in an effort to detect transforming genes in DNA from squamous carcinomas of the head and neck. Of 11 tumor DNAs tested, 1 DNA sample from a gingival squamous carcinoma was able to produce primary and secondary transformants containing the human K‐ras oncogene. This is the first report of an activated ras oncogene derived from a carcinoma of the head and neck. Head and neck cancers may possess activated ras oncogenes more often than is indicated by this study because of the relative inefficiency of transfection assays in detecting large transforming genes such as K‐ras.