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Assessment of the value of immunofluorescence microscopy in the diagnosis of oral mucosal lichen planus
Author(s) -
Firth N. A.,
Rich A. M.,
Radden B. G.,
Reade P. C.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00847.x
Subject(s) - medicine , oral lichen planus , dermatology , pathology , mucosal lesions , immunofluorescence , oral mucosa , direct fluorescent antibody , immunology , antibody
Accurate diagnosis of oral mucosal lichen planus (OMLP) is essential if appropriate management is to be instituted. Direct immunofluorescence microscopy (DIP) has facilitated the diagnosis of some dermatologic diseases with oral manifestations, but its use in the diagnosis of OMLP is less well documented. In the present study, 165 biopsies from consecutive cases for which a provisional diagnosis of OMLP was suggested clinically or on the basis of routine histopathologic, or DIP assessment were studied. In 27 cases the results of DIP were non‐contributory. In 13 cases the diagnosis could only be established by DIP examination. Nine cases clinically diagnosed as OMLP were assigned to a different condition on the basis of routine histology and DIP. It was concluded that DIP was an integral step in the diagnosis of OMLP.