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Immunohistochemical analysis of bone morphogenetic protein (BMP) in osteosarcoma
Author(s) -
Jin Y.,
Yang L. J.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00815.x
Subject(s) - osteosarcoma , bone morphogenetic protein , immunohistochemistry , fibrosarcoma , pathology , bone morphogenetic protein 2 , bone morphogenetic protein 7 , bone morphogenetic protein 5 , monoclonal antibody , cancer research , medicine , biology , antibody , immunology , in vitro , biochemistry , gene
The monoclonal antibody against bovine bone morphogenetic protein (bBMP‐McAb) was first used for demonstration of bone morphogenetic protein (BMP) in osteosarcoma. The avidin‐biotin complex method (ABC) demonstrated that of the 18 osteosarcomas, 15 stained positive, while all 6 fibrosarcomas were negative. The results showed that BMP mainly exists in the tumor cell plasma and some tumor‐like bone tissues. Using this staining method, we can not only differentiate osteosarcoma from fibrosarcoma and other non‐bone‐derived tumors, but also classify osteosarcoma according to the content and distribution of BMP and the patient's clinical situation, thus providing a scientific basis for clinical treatment.