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Fatty acid composition of clinically healthy and malignant oral epithelium
Author(s) -
Macleod R. I.,
Cassidy D.,
Laker M. F.,
Soames J. V.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00814.x
Subject(s) - palmitoleic acid , arachidonic acid , epithelium , basal cell , stearic acid , oleic acid , fatty acid , chemistry , palmitic acid , carcinoma , biochemistry , medicine , biology , pathology , enzyme , organic chemistry
The fatty acid composition of epithelium from clinically healthy oral mucosa and of oral squamous cell carcinoma was analyzed by gas/liquid chromatography following extraction using a modified Folch technique and conversion of fatty acids to methyl esters. There were significant reductions in the relative proportions of palmitoleic and oleic acids and elevation of the relative proportions of palmitic, stearic and arachidonic acids in samples from squamous cell carcinoma. These differences could reflect changes in cell membranes and/or fatty acid metabolism. Further studies are required to assess their functional, diagnostic and prognostic significance.