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Cytomegalovirus associated oral ulcerations in HIV‐infected patients
Author(s) -
Langford A.,
Kunze R.,
Timm H.,
Ruf B.,
Reichart P.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00799.x
Subject(s) - cytomegalovirus , medicine , saliva , pathology , oral mucosa , immunohistochemistry , antibody , virus , cytotoxic t cell , titer , immunology , viral disease , herpesviridae , biology , biochemistry , in vitro
Oral ulcerations associated with disseminated Cytomegalovirus (CMV) infection were observed in four patients with AIDS manifestations showing low CD4 counts. Virus cultures of urine and saliva samples were positive for CMV in all cases. The lesions were characterized by a punched‐out appearance, non‐indurated borders, low bleeding tendency and lack of inflammatory wall. Light microscopy revealed granulation tissue containing “owl's eye” like cells in all specimens. Presence of CMV was confirmed by immunohistochemistry and in situ hybridization. The ulcerations were infiltrated with T‐lymphocytes of the helper, suppressor and cytotoxic subset, most were positive for HLA DR. Despite the local invasion with immunocytes and high serum titers of serum antibodies the patients experienced progressive CMV disease.