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Induction and upregulation of adhesion receptors in oral and dermal lichen planus
Author(s) -
Konter U.,
Kellner I.,
Hoffmeister B.,
Sterry W.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00787.x
Subject(s) - receptor , immunoperoxidase , laminin , oral lichen planus , fibronectin , cell adhesion molecule , integrin , downregulation and upregulation , keratinocyte , basement membrane , oral mucosa , cell adhesion , adhesion , pathology , chemistry , biology , immunology , microbiology and biotechnology , medicine , in vitro , extracellular matrix , biochemistry , antibody , organic chemistry , monoclonal antibody , gene
The expression pattern of well‐defined cell surface adhesion receptors called VLA‐family, LFA‐1 and ICAM‐1 was determined semiquantitatively in biopsies of oral (n = 12) and dermal lichen planus (n = 5) and compared to normal uninvolved human oral mucosa (n= 12) and skin (n= 12) using an indirect immunoperoxidase technique. In both oral and dermal lichen planus, an induction of the β1‐integrins VLA‐1 and VLA‐3 and an upregulation of VLA‐6 was found on T cells infiltrating the basement membrane zone. These cell surface molecules function as receptors for collagen, fibronectin and laminin. A focal induction of ICAM‐1 on basal keratinocytes could be detected at sites of intramucosal T cells. These results suggest that investigated adhesion receptors are crucially involved in the aggregation of T cells in both conditions. Further investigations have to be done to determine the functional role of these adhesion receptors in lichen planus.