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Lingual fibrosarcoma induced by 7,12‐dimethylbenzanthracene in the rat
Author(s) -
Perrin C.,
Astre C.,
Broquerie E.,
Aubert B. Saint,
Joyeux H.
Publication year - 1990
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1990.tb00775.x
Subject(s) - fibrosarcoma , dmba , cachexia , medicine , respiratory tract , incidence (geometry) , cancer cachexia , pathology , cancer , physiology , respiratory system , carcinogenesis , physics , optics
A single injection of 5 mg of 7, 12‐dimethylbenzanthracene (DMBA) resulted in a high incidence of lingual fibrosarcoma in 67 Wistar rats. No metastases were found. We studied the influence of age and sex on the incidence, latency of tumors, loss of weight and the spontaneous survival of animals. The method described offers an experimental model for the study of cachexia resulting from upper digestive and respiratory tract cancer.