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Verapamil‐induced gingival overgrowth: a clinical, histologic, and biochemic approach
Author(s) -
Pernu Hilkka E.,
Oikarinen Kyösti,
Hietanen Jarkko,
Knuuttila Matti
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb01576.x
Subject(s) - verapamil , medicine , pathology , dentistry , cardiology , calcium
Verapamil‐induced overgrowth was most prominent in the anterior regions and interproximal areas associated with plaque retention. Despite periodontal therapy, overgrowths recurred 1 month after gingivectomy. Discontinuation of the drug resulted in regression of the overgrowths. Histologic findings showed inflamed connective tissue covered by an acanthotic, thickened oral epithelium with long rate pegs containing dyskeratotic pearls. The proliferation rate and protein and collagen production of fibroblasts from the overgrowth sites were markedly lower than in the control cells cultured from healthy gingiva. Incubation of fibroblasts in the presence of veraparnil reduced protein and collagen synthesis.