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Effects of chronic stimulation of salivary gland β‐adrenoceptors on saliva composition and caries development in the rat
Author(s) -
Ryberg M.,
Johansson I.,
Ericson T.,
Mörnstad H.,
Henriksson R.,
Jönsson G.,
Sundström S.
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb01357.x
Subject(s) - saliva , endocrinology , medicine , amylase , stimulation , submandibular gland , saline , parotid gland , chemistry , salivary gland , biology , enzyme , biochemistry , dentistry
The effects of long‐term β‐adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development.