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Histologic changes associated with the use of loose and portion‐bag packed Swedish moist snuff: a comparative study
Author(s) -
Andersson Gunilla,
Axéll Tony,
Larsson Ake
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb01349.x
Subject(s) - snuff , oral mucosa , medicine , dentistry , pathology
This study was to identify histologic tissue changes in the oral mucosa and to compare them in specimens from users of loose can‐packed and portion‐bag‐packed moist snuff. The material consisted of biopsies from 252 regular snuff users, 184 using exclusively loose and 68 portion‐bag snuff. An array of structural changes appearing in different combinations were identified among the 252 specimens. Two major patterns were recognized based on changes in the surface layer. Type 1 was characterized by an increased epithelial thickness with vacoulated cells and frequent chevron type changes. Type 2 showed a variably thickened surface layer with evidence of keratinization. Based on these findings, 14 carefully matched pairs of loose and portion‐bag users were analyzed and compared. Loose snuff users showed predominately histologic Type 1 changes while portion‐bag users showed more histologic Type 2 or only very discrete changes.