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Loss of Harvey ras heterozygosity in oral squamous carcinoma
Author(s) -
Howell R. E.,
Wong F. S. H.,
Fenwick R. G.
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb00741.x
Subject(s) - loss of heterozygosity , locus (genetics) , carcinogenesis , tumor suppressor gene , allele , squamous carcinoma , epidermoid carcinoma , carcinoma , biology , head and neck cancer , cancer research , heterozygote advantage , pathology , cancer , gene , genetics , medicine
This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c‐Ha‐ras‐1 locus and that the tumour from one patient had lost that heterozygosity. The loss of c‐Ha‐ras‐1 alleles provides a useful marker for detecting deletions of genetic material located on the short arm of chromosome 11 (lip) and has been found in association with a number of malignant tumours but has not been previously described in carcinoma of the head and neck. The repeated association of lip deletions with malignancies has led to the postulation of a recessive cancer gene or tumour suppressor gene at this location involved in carcinogenesis and tumour progression. This study indicates that such a mechanism may contribute to the development of oral squamous carcinoma.