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Expression of MHC Class II antigens (HLA DR, DP and DQ) by keratinocytes in oral lichen planus
Author(s) -
Farthing P. M.,
Cruchley A. T.
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb00402.x
Subject(s) - hla dr , keratinocyte , oral lichen planus , antigen , human leukocyte antigen , immunology , biology , major histocompatibility complex , pathology , medicine , cell culture , genetics
The incidence and distribution of keratinocytes expressing the major histocompatability complex antigens HLAJDR, DP and DQ and their relationship to the density of the inflammatory infiltrate was determined in lesions of oral lichen planus and normal mucosa using an immunoalkaline phosphatase technique. Seven of eight biopsies of lichen planus showed evidence of keratinocyte HLA DR expression but the pattern was variable both within and between biopsies. A significant increase in density of lymphocytes was found beneath those areas showing HLA DR expression throughout the prickle cell layer compared with those areas showing patchy or no expression. No evidence for keratinocyte expression of HLA DP or DQ was found. These results suggest that expression of HLA DR by keratinocytes in lichen planus may be induced by the lymphocytic infiltrate perhaps as a result of interferon gamma production. The functional significance of such MHC Class II expression remains unknown.