Premium
Replacement of Langerhans cells in murine palate
Author(s) -
Rittman B. R.,
Mackenzie I. C.,
Rittman G. A.
Publication year - 1989
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1989.tb00397.x
Subject(s) - hard palate , langerhans cell , biology , chemistry , andrology , endocrinology , medicine , microbiology and biotechnology , anatomy , immunology , surgery , antigen
Palates from C 3 H mice were implanted onto prepared graft beds in histocompatible Fl hybrid mice. Biopsies taken 1, 2, 4, 8, and 16 wk later were prepared to demonstrate Langerhans cells (LC) of C 3 H and Fl (host) origin. After 1 wk only occasional LC (all of C 3 H origin) were present. By 2 wk total LC numbers had increased to a level approximately 50% greater than in control (non‐implanted) palate, with most of this increase due to C 3 H LC proliferation. From 4 through 16 wk total LC numbers were not significantly different from those of control palate. During weeks 2 through 16 the percentages of LC of Fl origin were 31, 70, 39, and 19% respectively. These results indicate an increased proliferation of C 3 H LC with an initial migration of Fl LC which stops as C 3 H LC numbers increase.