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Laminin: molecular Organization and biological function
Author(s) -
Campbell J. H.,
Terranova V. P.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01543.x
Subject(s) - laminin , basement membrane , glycoprotein , microbiology and biotechnology , biology , function (biology) , metastasis , membrane glycoproteins , biochemistry , extracellular matrix , cancer , genetics
Laminin, the most abundant glycoprotein molecule found in basement membrane, has multiple functions in eukaryotic tissues. It serves to attach epithelial cells to basement membrane, aids development and migration of specific cell types in growth and maturation, and has been implicated in tumor metastasis and some types of infection. Current concepts of the molecular organization and myriad functions of the laminin molecule are reviewed.