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The proportion of suppressor‐inducer T‐lymphocytes is reduced in recurrent aphthous stomatitis
Author(s) -
Savage N.W.,
Mahada R.,
Seymour G.J.,
Bryson G.J.,
Collins R.J.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01539.x
Subject(s) - recurrent aphthous stomatitis , cd8 , lymphocyte , t lymphocyte , immunology , peripheral blood , medicine , monoclonal antibody , peripheral blood lymphocyte , stomatitis , antibody , immune system
A flow cytometric analysis of peripheral blood lymphocytes was undertaken in recurrent aphthous stomatitis patients. The project aimed at detecting differences within lymphocyte subsets using type‐specific monoclonal antibodies. Peripheral blood samples were taken from RAS patients in both active and remission phases of the disease and from a group of healthy control subjects. There were no statistical differences between the active and remission phases within any of the lymphocyte subsets examined. There was, however, a significant difference between the RAS group and the control group. RAS patients have depressed CD4+ cell numbers and elevated CD8+ cell numbers. The CD4: CDS ratio is also depressed. A dissection of the CD4+ subset shows raised numbers of CD4+, 4B4+ lymphocytes and depressed numbers of CD4+, 2H4+ lymphocytes. Previous studies have shown disruption of peripheral blood lymphocyte numbers in Behcets syndrome. A similar pattern has now been shown in uncomplicated cases of minor RAS.