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Immunohistochemical staining for vimentin filaments and S‐100 protein in myxoma of the jaws
Author(s) -
Lombardi T.,
Kuffer R.,
Bernard J.P.,
FioreDonno G.,
Samson J.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01520.x
Subject(s) - vimentin , immunohistochemistry , pathology , staining , myxoma , intermediate filament , medicine , biology , cytoskeleton , cell , biochemistry
Two jaw myxomas have been analyzed by a panel of antibodies to characterize this tumour type. Vimentin, but not keratin, neuron‐specific enolase (NSE), glial fibrillary acidic protein (GFAP), neurofilament (NF), desmin and Factor VIII‐related antigen (FVIII‐AG), demonstrated positivity in the cytoplasm of the neoplastic cells. Moreover, an antibody against S‐100 protein also showed a strong positive reaction in the cytoplasm of the tumour cells examined. Thus directly indicating a mesenchymal derivation for odontogenic myxoma, and is the first demonstration of S‐100 protein within the cells of this tumour type.