Premium
Osteoclast activating factor is now interleukin‐1 beta: historical perspective and biological implications
Author(s) -
Jandinski J. J.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01515.x
Subject(s) - mediator , osteoclast , immunology , pathological , interleukin , biology , medicine , cytokine , microbiology and biotechnology , receptor , pathology , genetics
Interleukin‐1 (IL‐1) represents a family of polypeptides with widespread immunological and non‐immunological activity. Recent studies show that Osteoclast activating factor (OAF) is homologous to IL‐1B. In this review, the biological properties, cell sources and actions of IL‐1 are discussed. The numerous biological effects of IL‐1 on various host systems suggest that elevated levels of the mediator may be an indicator of a pathological process. Since the IL‐1 family plays an important role as a key mediator of the inflammatory, immunological and bone resorptive responses it is of considerable concern to dentists.