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Dentin in chronic renal failure: an ultrastructural study
Author(s) -
Clark D. B.,
Wysocki G. P.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01508.x
Subject(s) - dentin , hemodialysis , chronic renal failure , ultrastructure , medicine , pathophysiology , kidney disease , calcium , pathology , dentistry , physiology
Disturbances in the mineralization of hard tissues in patients suffering from chronic renal failure and in patients undergoing chronic hemodialysis are a well‐established phenomenon. These disturbances are the result of complex pathophysiologic alterations in calcium and phosphorus metabolism. Disturbances in the dentin of teeth, analagous to those occurring in bone, were not recognized until 1983 when it was reported that a significantly thicker pre‐dentin layer was present in the teeth of patients with chronic renal failure and in patients being treated with chronic hemodialysis (1). The aim of the present study was to conduct a comparative ultrastructural (SEM) analysis of dentin in this group of patients. A wide spectrum of changes was detected, ranging from mild disturbances with increasing tubule irregularity and focal obliteration of tubule lumens, to widespread formation of dysplastic dentin exhibiting numerous mineralized, largely atubular globules with only occasional large, irregular tubules. In general, these changes appeared to reflect the type and effectiveness of treatment rendered (renal transplant or hemodialysis therapy). The findings suggest that dentin exhibits significant ultrastructural alterations when the underlying homeostatic regulation of calcium and phosphorus metabolism is disturbed in systemic disorders such as chronic renal failure.