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The regulation of Langerhans cell T6, DR and DQ antigen expression: an hypothesis
Author(s) -
Walsh L. J.,
Seymour G. J.,
Powell R. N.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01504.x
Subject(s) - antigen , immunology , biology , in vitro , human leukocyte antigen , in vivo , population , interleukin , microbiology and biotechnology , cytokine , medicine , biochemistry , environmental health
A hypothetical model of the maturation pathway of Langerhans cells (LC) within an epithelial environment is presented. This model is based on in vitro studies using human gingival organ culture. In this model, T6 (GD1) antigen is induced on a T6(‐) intraepithelial population by Interleukin‐1 secreted by epithelial cells. This process is abrogated by a locally produced Interleukin‐1 inhibitor, ILS. These T6(+) LC then express first HLA‐DR and subsequently HLA‐DQ surface antigens under the influence of either lipopolysaccharide or gamma interferon. The induction of these Class II antigens on LC is inhibited by prostaglandin E 2 . It is postulated that these Class II antigen positive LC are then available to function as antigen presenting cells. This hypothesis is consistent with in vitro studies and several in vivo observations. The basis of the hypothesis is the demonstration that locally produced factors may exert an influence on LC behaviour within an epithelial environment.