Premium
Multiple myeloma and amyloidosis of the tongue
Author(s) -
Raubenheimer E. J.,
Dauth J.,
Pretorius F. J.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01333.x
Subject(s) - multiple myeloma , amyloidosis , tongue , medicine , al amyloidosis , pathology , dermatology , macroglossia , immunology , immunoglobulin light chain , antibody
Tongue biopsies of 30 diagnosed cases of multiple myeloma were examined light and electron microscopically and amyloid deposits were identified in 8 patients. Immunochemical typing of amyloid in kappa and lambda subtypes was performed successfully although positive staining of tissue‐associated immunoglobulin light chains made reliable identification of amyloid with this technique difficult. Cells of macrophage lineage appear to play a central role in light chain‐associated amyloidogenesis. Our findings do not agree with the reported higher amyloidogenic potential of lambda light chains and we were unable to show a positive correlation between the percentage plasma cells in bone marrow aspirates or the presence of urinary light chains and myeloma‐associated amyloidosis.