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Local infusion of prostaglandin E 1 stimulates mandibular bone formation in vivo
Author(s) -
Marks S. C.,
Miller S.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01324.x
Subject(s) - beagle , medicine , dental alveolus , dentistry , bone resorption , bone formation , in vivo , resorption , dentition , alveolar ridge , mandible (arthropod mouthpart) , pathology , surgery , biology , implant , botany , genus , microbiology and biotechnology
The maintenance of alveolar bone is a major clinical objective in dentistry. This is particularly difficult following such local inflammatory episodes as those of periodontitis or the loss of dentition (residual ridge resorption). We present evidence from beagle dogs that local infusion of prostaglandin E 1 (PGE) for 3 weeks at doses of 500 to 2000μg per week produces a dramatic, localized formation of alveolar bone in the mandible which exhibits a normal lamellar architecture and mineralization pattern when evaluated by fluorescence microscopy and microradiography. Whether this newly formed bone becomes functionally integrated into the skeleton and can replace bone lost from surgical resections or trauma remains to be established. Nevertheless, these data indicate that predictable local osteogenesis may eventually be produced by infusions of PGE.