Premium
Expression of endothelial cell markers PAL‐E and EN‐4 and la‐antigens in Kaposi's sarcoma
Author(s) -
Nadimi H.,
Saatee S.,
Armin A.,
Toto P. D.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01307.x
Subject(s) - lymphatic system , lymphatic endothelium , pathology , high endothelial venules , biology , antigen , immunohistochemistry , endothelium , antibody , endothelial stem cell , monoclonal antibody , sarcoma , microbiology and biotechnology , immunology , medicine , biochemistry , in vitro , endocrinology
Eleven biopsy specimens of Kaposi's sarcoma (KS) removed from the skin and oral mucosa were examined immunohistochemically with monoclonal antibodies PAL‐E and EN‐4, specific for human vascular endothelial cells, and with LN‐3 monoclonal antibody reactive with immune‐associated (la) antigens in the HLA‐DR locus. The early lesions of KS, corresponding to the patch phase, contained hyperplastic venules and an increased number of lymphatic capillaries. The lymphatic capillary endothelium was reactive with EN‐4, whereas, PAL‐E reacted only with blood vessel endothelial cells. The spindle cells, like lymphatic endothelial cells, were non‐reactive with PAL‐E but showed positive reaction with EN‐4 antibodies. The observed morphologic pattern of vasculogenesis and the demonstrated immune‐reactivity in KS support an origin from the venul‐lymphatic junction. This is an aberrant pattern but reminiscent of normal embryonal lymphatic channel development. The lymphatic capillaries and vascular slits were nonreactive with LN‐3 antibody, but it was positive on cell membranes in a number of spindle cells, suggesting the focal expression of la‐anitgens.