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Immunoelectron microscopical localization of immunoglobulins, secretory component and J chain in the human minor salivary glands
Author(s) -
Sumi Y.,
Nagura H.,
Kaneda T.,
Oka T.
Publication year - 1988
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1988.tb01303.x
Subject(s) - j chain , secretory component , saliva , immunoelectron microscopy , salivary gland , antibody , immunoglobulin a , biology , cytoplasm , chemistry , microbiology and biotechnology , pathology , immunology , immunoglobulin g , biochemistry , medicine
Localization of IgA, secretory component (SC) and J chain was investigated immunocytochemically in minor salivary glands of the lip and palate to define the mechanism involved in the transport of immunoglobulin A (slgA) into the saliva from the minor salivary glands. SC synthesis was detected in mucous acinar cells and ductal epithelial cells. Free SC is secreted into the saliva through secretory granules in the mucous acinar cells. Dimeric IgA containing J chain is translocated through these cells as slgA by a SC‐medialed transport mechanism involving cytoplasmic vesicles.