Premium
Treatment of aphthous patients by enhancement of the salivary peroxidase system
Author(s) -
Hoogendoorn H.,
Piessens J. P.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb02080.x
Subject(s) - peroxidase , saliva , medicine , hydrogen peroxide , exacerbation , toothpaste , amylase , dermatology , gastroenterology , dentistry , chemistry , enzyme , biochemistry
Hoogendoorn H, Piessens JP. Treatment of aphthous patients by enhancement of the salivary peroxidase system. J Oral Pathol 1987: 16: 425–427. The inhibition of glucose‐stimulated acid production by indigenous bacteria in human saliva is not achieved by the addition of up to 250 (μM hydrogen peroxide in vitro. However, in the presence of 2 × 10 ‐4 % of hydroxyquinoline and the same amount of Zn, acid production is immediately terminated by addition of peroxide to only 25 μM. No inhibition is observed when any one of these components is omitted. On the basis of these observations, a mouthrinse containing the same concentrations of hydroxyquinoline and Zn was prepared. Hydrogen peroxide was provided by including glucose oxidase and amyloglucosidase. This mouthrinse was used in a pilot clinical study of 64 patients subject to severe aphthous attacks which were not previously relieved by the use of a peroxidogenic toothpaste. After a two‐month period, during which these patients rinsed twice daily with 5 ml of the mouthrinse, 45 patients reported relief of their symptoms. Of the remaining 19 patients, 17 reported no effect of using the mouthrinse, while 2 reported an exacerbation of their symptoms. The results of this study suggest that the mothrinse may be an effective method for treating patients who suffer from severe aphthous attacks.