Premium
Surface ultrastructural changes in chemically induced premalignant lesions in the hamster cheek pouch
Author(s) -
Hassanin M. B.,
Ashrafi S. H.,
Das A. K.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb01492.x
Subject(s) - cheek pouch , dmba , cheek , pathology , ultrastructure , hamster , epithelium , scanning electron microscope , electron microscope , biology , carcinogenesis , chemistry , anatomy , medicine , materials science , microbiology and biotechnology , cancer , optics , physics , genetics , composite material
The histopathological and topographical alterations occurring during the early stages of chemical carcinogenesis in the hamster cheek pouch using 7, 12‐dimethylbenz (α) anthracene (DMBA) were studied by light and scanning electron microscopy. At the scanning electron microscopic level, cellular overlapping and mild disturbance of intercellular bridges were noticed as early as the second week of DMBA application; these changes progressed with time. Clear epithelial dysplastic changes at the light microscopic level were detected by the sixth week of the experiment. The results of this investigation demonstrate the usefulness of scanning electron microscopy as an adjunct tool to study early alterations in cell morphology which occur in the stratified squamous epithelium of the hamster cheek pounch in response to a chemical carcinogen.