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Demonstration of human papillomavirus DNA in oral condyloma acuminatum
Author(s) -
Eversole L. R.,
Laipis P. J.,
Merrell P.,
Choi E.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb01491.x
Subject(s) - koilocyte , condyloma acuminatum , human papillomavirus , biology , pathology , tongue , verruca vulgaris , in situ hybridization , epidermodysplasia verruciformis , virus , virology , gene , medicine , cancer , cervical cancer , genetics , cervical intraepithelial neoplasia , gene expression
Condyloma acuminatum arising on oral mucous membranes exhibits distinct histopathologial features that allow for differentiation from the more common squamous papilloma. These lesions are parakeratinized with cryptic invagination of cornified cells extending into an acanthotic spinous cell layer. Superficial spinous layer koilocytosis is a prominent feature and the condylomatous papillomas exhibit a tendency for sessile architecture. Among 62 instances, the average age was 39.7 years with a predilection for the 3rd and 4th decades. The male to female ratio was 5.7:1 and the tongue, gingiva and lips were the favored sites. Whereas 25% of the evaluated cases demonstrated upper spinous layer papillomavirus common antigen immunoreactivity, DNA in situ hybridization under conditions of high stringency disclosed the presence of human papillomavirus Types 6, 11 or related genomes in 85% of the lesions. A single case was found to harbor human papillomavirus Type 2.