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DNA‐ploidy studies in a keratocyst undergoing subsequent malignant transformation
Author(s) -
High A. S.,
Quirke P.,
Hume W. J.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb01480.x
Subject(s) - keratocyst , pathology , malignant transformation , flow cytometry , biology , odontogenic , basal cell , epithelium , medicine , microbiology and biotechnology
Using techniques that allow flow cytometry to be performed on tissue stored in paraffin wax, we have examined the DNA content of cells from an odontogenic keratocyst which underwent malignant transformation. On histological examination, the primary lesion was an odontogenic keratocyst showing dysplastic changes within the squamous epithelium. Flow cytometry revealed a prominent, abnormal DNA stemline, which was also present in the subsequent squamous cell carcinoma.