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Evaluation of the Ca 1 monoclonal antibody in distinguishing oral squamous cell carcinoma from non‐malignant or premalignant oral lesions
Author(s) -
Masouredis C.M.,
Green T.L.,
Greenspan J.S.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb00699.x
Subject(s) - monoclonal antibody , medicine , basal cell , pathology , carcinoma , premalignant lesion , oral cancers , antibody , cancer , immunology
The Ca antigen has been reported to be present on the surface of malignant but not, with few exceptions, non‐malignant cells. We investigated the potential usefulness of the monoclonal Ca 1 antibody in differentiating oral squamous cell carcinoma from non‐malignant or premalignant oral neoplasms. Paraffin‐embedded sections from 33 biopsy specimens of 12 hyperplastic and 21 neoplastic oral lesions were examined by immunohistochemical staining. Seven of the 33 specimens showed positive staining for Ca antigen. Fifteen of 21 specimens of oral squamous cell carcinoma were negative for Ca antigen, and one case of focal keratosis was positive. The results indicate that the use of the Ca 1 antibody to distinguish oral squamous cell carcinoma from non‐malignant or premalignant oral lesions is highly unreliable.