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Carcinogenic response of hamster buccal pouch epithelium to 4 polycyclic aromatic hydrocarbons
Author(s) -
Soil D. B.,
Polverini P. J.,
Calderon L.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb00697.x
Subject(s) - carcinogen , epithelium , cheek pouch , hamster , buccal administration , pathology , biology , chemistry , medicine , microbiology and biotechnology , biochemistry , bioinformatics
In order to assess the relative carcinogenic potency of polycyclic aromatic hydrocarbons in hamster buccal pouch, groups of male Syrian golden hamsters were treated by painting the buccal pouch surfaces for up to 20 weeks with equimolar concentrations of 7, 12‐dimelhylbenzanthracenc; benzanthracene, 3,4‐bcnzpyrene; or 20‐methylcholanthrenc dissolved in paraffin oil. Control hamsters were simarily treated with paraffin oil. Whereas 100% of the 7, 12‐dimethylbenzanthraccne treated hamsters developed buccal pouch carcinomas within the 20‐week treatment period, no cancers were observed in the control hamsters or in those treated with the other polycyclic aromatic hydrocarbons. Simarily, of the various treatment groups, only 7,12‐dimethylbenzanthraccnc treated hamsters displayed the efficient induction of foci of intense gamma glutamyltranspeptidase (GGT) histochemical activity within the buccal pouch epithelium. These results support the working hypothesis that induction of GGT foci is an early indicator of developing carcinoma in this experimental model.