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Experimental extra‐follicular histogenesis of follicular cysts
Author(s) -
Altini M.,
Cohen M.
Publication year - 1987
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1987.tb00686.x
Subject(s) - follicular cyst , anatomy , histogenesis , deciduous teeth , keratocyst , cyst , biology , pathology , follicular phase , epithelium , tooth eruption , premolar , medicine , dentistry , molar , immunohistochemistry , paleontology , endocrinology
An animal model has been developed in which implantation cysts have been produced very close to developing teeth within the jaws of Vervet monkeys. Various deciduous teeth were extracted from both the maxilla and the mandible of 6 young Vervel monkeys. After 4 weeks, full thickness mucoperiosteal flaps were raised in these areas, up to 6 recipient sites were prepared in each monkey by drilling holes in the alveolar bone and small pieces of autogenous palatal mucosa were placed in these graft recipient sites. One monkey was killed after 5, 8, 22 and 25 weeks respectively and 2 after 52 weeks. Of the 33 implants placed, cyst formation occurred from 11 (33%). The distribution of the cysts was irregular in that 4 cysts were produced in each of 2 animals while no cysts were found in another 2 animals. The cysts produced were filled with keratin and lined partly by a thick keratinising epithelium and partly by a thin non‐keratinising epithelium only a few cell layers thick. In one of the animals killed after 52 weeks, (he follicle of an erupting premolar tooth had collided with one of the cysts resulting in the cyst lining becoming incorporated into the follicle, partly replacing the follicular reduced enamel epithelium and forming now an integral part of the follicle. This observation supports the hypothesis that the follicular odontogenic keratocyst has an extra‐follicular origin arising alter the eruption of a tooth into a pre‐existing cyst cavity.